2B4 anticorps

N° du produit ABIN2689111

Cet anticorps anti-2B4 est un anticorps Souris Monoclonal détectant 2B4 dans FACS. Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour 2B4 anticorps (ABIN2689111)

Antigène: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp 2B4 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 2

Détail du produit anti-2B4 anticorps

Marque: BD Pharmingen™

Attributs du produit: Reacts with a 66 kDa single chain transmembrane glycoprotein. 2B4 belong to the immunoglobulin superfamily of proteins and is structurally related to CD2-like molecules. It was originally identified in the mouse as a non-MHC-restricted cytotoxicity mediator present on NK cells and CD8+ T cells. In humans, 2B4 is expressed on NK cells, CD8+ T cells, monocytes and basophils, suggesting a broader role for 2B4 in leukocyte activation and possibly a role of immunomodulation in other receptor-ligand interactions to enhance leukocyte activation. 2B4 has been clustered as CD244 in the VIIth HLDA workshop. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of CD244 (2-69) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD244 - Purified - Clone 2-69 - Isotype Mouse IgG2a, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-2B4 (ABIN2689111)

Sivori, Parolini, Falco, Marcenaro, Biassoni, Bottino, Moretta, Moretta: "2B4 functions as a co-receptor in human NK cell activation." dans: European journal of immunology, Vol. 30, Issue 3, pp. 787-93, (2000) (PubMed).

Nakajima, Cella, Langen, Friedlein, Colonna: "Activating interactions in human NK cell recognition: the role of 2B4-CD48." dans: European journal of immunology, Vol. 29, Issue 5, pp. 1676-83, (1999) (PubMed).

Tangye, Lazetic, Woollatt, Sutherland, Lanier, Phillips: "Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 6981-5, (1999) (PubMed).

Mathew, Garni-Wagner, Land, Takashima, Stoneman, Bennett, Kumar: "Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 10, pp. 5328-37, (1993) (PubMed).

Détails sur 2B4

Antigène: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Autre désignation: CD244

Sujet: Synonyms: 2B4